My Little Brony.

Three of my closest friends from high school went to A&M College Station. They are all guys, and would probably be classified as the nerdier, video game loving type. As they are part of my circle of friends that I try very hard to keep in touch with, I make sure to check up on their Facebook pages at least once a week.
Something I have noticed is that they consistently post photos of a parody show of the "My Little Pony" series, known as "My Little Brony." This actually didn't surprise me at all. These guys had all gone through the "Bro" phrase. ["Dude that's so brotastic. Hannah Brotanna, etc.]
Curious, I looked up "My Little Brony" online and was led to multiple episodes, shirts, and iterations of the meme. What I found to be effective of this meme was that there were versions of it that were iterations of other memes. For example, IDGAF, Derp, Over 9000, and much more. One of my friends, had even been creating his own versions of this meme by photoshopping his own inside jokes onto photos from the show.
I believe this is a prime example of how a meme can stay alive for an extended amount of time on the Internet. Because "My Little Brony" has so many episodes online and are pumping out more, fans have the ability to create more and more versions of the meme online, prolonging it's life.
In my opinion, "My Little Brony" is not humorous at all, but to my three good friends, it's a show where they anxiously wait for new episodes. This supports how target audience is also key to a meme's survival.